Similac Pro-Total Comfort – 22.5 oz – Powder – 4 Pack

Add to compare

Most gentle formula with 2’-FL HMO for immune support.


Best deal at:
Similac Pro-Total Comfort – 22.5 oz – Powder – 4 Pack
Similac Pro-Total Comfort – 22.5 oz – Powder – 4 Pack



Switching formulas due to a baby’s sensitive tummy can be overwhelming. At Similac®, we promise to support you on your journey of nourishing your baby and her unique nutrition needs.

The Similac Pro-Total Comfort Difference

  • Our most gentle formula with 2’-FL HMO for immune support and our unique blend of DHA and Lutein for brain and eye development
  • 1 Day—less crying, less fussiness, and less gas
  • Partially hydrolyzed protein for easy digestion
  • No artificial growth hormones
  • Makes 4 more 6-fl-oz bottles vs Enfamil NeuroPro Gentlease®

Gentle formula with partially hydrolyzed protein

Similac Pro-Total Comfort is the first gentle formula with partially hydrolyzed protein and 2’-FL Human Milk Oligosaccharide (HMO), an immune-nourishing prebiotic like that found in breast milk. HMOs feed good bacteria in the gut, where 70% of the immune system exists. Similac with 2’-FL HMO helps strengthen baby’s immune system to be more like the breastfed infant than ever before.

Parents reported a significant reduction in fussiness, gassiness, and crying after just 1 day of feeding.

Designed for delicate tummies

Similac Pro-Total Comfort with 2’FL HMO is an easy-to-digest, gentle formula that’s designed for delicate tummies. It’s a good choice if your child has difficulty tolerating other milk-based formulas.

Exclusive blend of nutrients

Our exclusive blend has DHA, Lutein, and Vitamin E—important ingredients found in breast milk. DHA supports brain development, Lutein supports eye health, and Vitamin E is an important nutrient that supports developing cells.


Additional information

Specification: Similac Pro-Total Comfort – 22.5 oz – Powder – 4 Pack

Weight 90 oz


Age Group

0-12 months



Unit Net Weight (Oz)


Total Net Weight (Oz)


Base Ingredient



added prebiotics, gluten free, iron-fortified, lactose sensitivity, non-GMO


brain development, crying reduction, easy to digest, eye development, fussiness reduction, gassiness reduction, growth support, immune system support


Videos: Similac Pro-Total Comfort – 22.5 oz – Powder – 4 Pack

Price History

Infant Formula Price Comparison
Enable registration in settings - general
Compare items
  • Total (0)